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 | Acesso ao texto completo restrito à biblioteca da Embrapa Pecuária Sudeste. Para informações adicionais entre em contato com cppse.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
09/11/2017 |
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Data da última atualização: |
21/11/2017 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SILVA, I. C. da; MAGALHAES, P. M. de; SOUSA, I. M. de O.; FOGLIO, M. A.; LEONARDECZ, E.; ESTEVES, S. N.; CHAGAS, A. C. de S. |
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Afiliação: |
Ives Charlie da Silva, UNESP; Pedro Melillo de Magalhães, UNICAMP; Ilza Maria de Oliveira Sousa, UNICAMP; Mary Ann Foglio, UNICAMP; Eduardo Leonardecz, UFSCar; SERGIO NOVITA ESTEVES, CPPSE; ANA CAROLINA DE SOUZA CHAGAS, CPPSE. |
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Título: |
Anthelmintic activity of Artemisia annua in sheepmodel. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Journal of Medicinal Plants Research, v. 11, n. 7, p. 137-143, 2017. |
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DOI: |
10.5897/JMPR2016.6318 |
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Idioma: |
Inglês |
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Conteúdo: |
Artemisia annua L. is a well-known source of artemisinin, an antimalarial drug. This compound has been used in traditional medicine to treat malaria for many years. The anthelmintic property of A. annua has also been attributed to artemisinin, hence the belief that artemisinin could be useful as an alternative anthelmintic to control Haemonchus contortus in livestock. The present study focused on evaluating the anthelmintic activity of A. annua against H. contortus by oral administration on infected sheep in a controlled clinical trial. The trial was conducted using 24 male sheep of the Santa Inês breed, with average weight of 20 kg, artificially infected with H. contortus (Embrapa 2010 isolate). The animals were kept in metabolic cages and randomly divided into four homogeneous groups with six animals each, being: (T1) negative control (untreated), (T2) positive control: 10 mg/kg BW of levamisole phosphate, (T3) fed 10% A. annua (0.2% BW), (T4) fed 20% A. annua (0.4% BW). EPG counts were conducted on days -3, -2, -1, 0 (treatment day), 3, 7, 10, 14, 17, 21, 24 and 28 post-treatment. After extraction of the artemisinin in plant material, it was quantified in triplicate and analyzed by high-performance liquid chromatography with infrared detection. The average efficacy in the positive control treated with levamisole was 89%. Moderate anthelmintic efficacy against H. contortus was observed in the groups fed 0.2 and 0.4% BW A. annua for 30 days (32.9 and 14.8%, respectively), mainly from day 21 post treatment (47.1 and 25.2%, respectively). At the highest dose, the animals avoided eating due to the compound?s bitter taste. It is concluded that A. annua presents moderate anthelmintic activity in sheep in both doses. The lowest dose was accepted by animals and seems to have practical use. Oral administration was safe and after further in vivo trials could be introduced in organic farms in tropical countries. MenosArtemisia annua L. is a well-known source of artemisinin, an antimalarial drug. This compound has been used in traditional medicine to treat malaria for many years. The anthelmintic property of A. annua has also been attributed to artemisinin, hence the belief that artemisinin could be useful as an alternative anthelmintic to control Haemonchus contortus in livestock. The present study focused on evaluating the anthelmintic activity of A. annua against H. contortus by oral administration on infected sheep in a controlled clinical trial. The trial was conducted using 24 male sheep of the Santa Inês breed, with average weight of 20 kg, artificially infected with H. contortus (Embrapa 2010 isolate). The animals were kept in metabolic cages and randomly divided into four homogeneous groups with six animals each, being: (T1) negative control (untreated), (T2) positive control: 10 mg/kg BW of levamisole phosphate, (T3) fed 10% A. annua (0.2% BW), (T4) fed 20% A. annua (0.4% BW). EPG counts were conducted on days -3, -2, -1, 0 (treatment day), 3, 7, 10, 14, 17, 21, 24 and 28 post-treatment. After extraction of the artemisinin in plant material, it was quantified in triplicate and analyzed by high-performance liquid chromatography with infrared detection. The average efficacy in the positive control treated with levamisole was 89%. Moderate anthelmintic efficacy against H. contortus was observed in the groups fed 0.2 and 0.4% BW A. annua for 30 days (32.9 and 14.8%, respectively), m... Mostrar Tudo |
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Thesaurus Nal: |
artemisinin; gastrointestinal nematodes; sesquiterpenoids. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02655naa a2200241 a 4500
001 2079284
005 2017-11-21
008 2017 bl uuuu u00u1 u #d
024 7 $a10.5897/JMPR2016.6318$2DOI
100 1 $aSILVA, I. C. da
245 $aAnthelmintic activity of Artemisia annua in sheepmodel.$h[electronic resource]
260 $c2017
520 $aArtemisia annua L. is a well-known source of artemisinin, an antimalarial drug. This compound has been used in traditional medicine to treat malaria for many years. The anthelmintic property of A. annua has also been attributed to artemisinin, hence the belief that artemisinin could be useful as an alternative anthelmintic to control Haemonchus contortus in livestock. The present study focused on evaluating the anthelmintic activity of A. annua against H. contortus by oral administration on infected sheep in a controlled clinical trial. The trial was conducted using 24 male sheep of the Santa Inês breed, with average weight of 20 kg, artificially infected with H. contortus (Embrapa 2010 isolate). The animals were kept in metabolic cages and randomly divided into four homogeneous groups with six animals each, being: (T1) negative control (untreated), (T2) positive control: 10 mg/kg BW of levamisole phosphate, (T3) fed 10% A. annua (0.2% BW), (T4) fed 20% A. annua (0.4% BW). EPG counts were conducted on days -3, -2, -1, 0 (treatment day), 3, 7, 10, 14, 17, 21, 24 and 28 post-treatment. After extraction of the artemisinin in plant material, it was quantified in triplicate and analyzed by high-performance liquid chromatography with infrared detection. The average efficacy in the positive control treated with levamisole was 89%. Moderate anthelmintic efficacy against H. contortus was observed in the groups fed 0.2 and 0.4% BW A. annua for 30 days (32.9 and 14.8%, respectively), mainly from day 21 post treatment (47.1 and 25.2%, respectively). At the highest dose, the animals avoided eating due to the compound?s bitter taste. It is concluded that A. annua presents moderate anthelmintic activity in sheep in both doses. The lowest dose was accepted by animals and seems to have practical use. Oral administration was safe and after further in vivo trials could be introduced in organic farms in tropical countries.
650 $aartemisinin
650 $agastrointestinal nematodes
650 $asesquiterpenoids
700 1 $aMAGALHAES, P. M. de
700 1 $aSOUSA, I. M. de O.
700 1 $aFOGLIO, M. A.
700 1 $aLEONARDECZ, E.
700 1 $aESTEVES, S. N.
700 1 $aCHAGAS, A. C. de S.
773 $tJournal of Medicinal Plants Research$gv. 11, n. 7, p. 137-143, 2017.
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Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
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| Registros recuperados : 14 | |
| 1. |  | LIMA, T. B.; GROSSI DE SÁ, M. F.; FRANCO, O. L.; LEONARDECZ, E. Phytochemistry characterization of the effect of Cagaita (Eugenia dysenterica) in laxative and antidiarreic compound. In: ANNUAL MEETING OF THE SBBq, 36.; IUBMB CONFERENCE, 10., 2007, Salvador, BA. Infectious diseases: biochemistry of parasites, vectors and hosts. [S.l.]: SBBq, 2007. Não paginado.| Tipo: Resumo em Anais de Congresso | Circulação/Nível: -- - -- |
| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 5. | | SILVA, I. C. da; MAGALHAES, P. M. de; SOUSA, I. M. de O.; FOGLIO, M. A.; LEONARDECZ, E.; ESTEVES, S. N.; CHAGAS, A. C. de S. Anthelmintic activity of Artemisia annua in sheepmodel. Journal of Medicinal Plants Research, v. 11, n. 7, p. 137-143, 2017.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 3 |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 6. | | LAUMANN, R. A.; MORAES, M. C. B.; PAREJA, M.; ALARCÃO, G. C.; BOTELHO, A. C.; MAIA, A. H. N.; LEONARDECZ, E.; BORGES, M. Comparative biology and functional response of Trissolcus spp. (Hymenoptera: Scelionidae) and implications for stink bugs (Hemiptera: Pentatomidae) biological control. Biological Control, v. 44, p. 32-41, 2008.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: Internacional - A |
| Biblioteca(s): Embrapa Meio Ambiente; Embrapa Recursos Genéticos e Biotecnologia. |
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| 7. | | FÁVERO, A. P.; SILVA, P. A. P.; ALVES, E. E. A.; CUSTODIO, A. R.; SCHMIDT, A. B.; TEIXEIRA, M. A.; MARTINS, A. E.; LEONARDECZ, E. Obtenção de híbridos entre anfidiplóides sintéticos de Arachis e o amendoim cultivado. In: CONGRESSO BRASILEIRO DE MELHORAMENTO DE PLANTAS, 4., 2007, São Lourenço. Anais... São Lourenço: Sociedade Brasileira de Melhoramento de Plantas, 2007.| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 8. | | CARMO, L. S. T.; CÂNDIDO, E. S.; CAMPOS, P. F.; QUEZADO-DUVAL, A. M.; LEONARDECZ, E.; LOPES, C. A.; QUIRINO, B. F. Natural variability in Arabidopsis thaliana germplasm response to Xanthomonas camprestris pv. campestris. Fitopatologia Brasileira, Brasília, DF, v. 32, n. 2, p. 97-103, mar./abr. 2007| Tipo: Artigo em Periódico Indexado | Circulação/Nível: Nacional - A |
| Biblioteca(s): Embrapa Hortaliças. |
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| 9. | | DINATO, N. B.; SANTOS, I. R. I.; LEONARDECZ, E.; BURSON, B. L.; QUARÍN, C. L.; PAULA, A. F. de; FAVERO, A. P. Storage of bahiagrass pollen at different temperatures. Crop Science, v. 58, n. 6, p. 2391-2398, 2018.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 11. | | ABUD, S.; SOUZA, P. I. M. de; VIANNA, G. R.; LEONARDECZ, E.; MOREIRA, C. T.; FALEIRO, F. G.; NUNES JÚNIOR, J.; MONTEIRO, P. M. F. O.; RECH, E. L.; ARAGÃO, F. J. L. Gene flow from transgenic to nontransgenic soybean plants in the Cerrado region of Brazil. Genetics and Molecular Research, Ribeirão Preto, v. 6, n. 2, p. 345-352, 2007.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: Internacional - A |
| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 12. | | SILVA, S. A. da; SOUZA, P. I. de M. de; VIANNA, G. R.; LEONARDECZ, E.; MOREIRA, C. T.; FALEIRO, F. G.; NUNES JÚNIOR, J.; MONTEIRO, P. M. F. O.; RECH FILHO, E. L.; ARAGÃO, F. J. L. Gene flow from transgenic to nontransgenic soybean plants in the Cerrado region of Brazil. Genetics and Molecular Research, v. 6, n. 2, p. 345-352, 2007.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: Internacional - A |
| Biblioteca(s): Embrapa Cerrados. |
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| 13. | | LIMA, T. B.; NASCIMENTO SILVA, O.; ROCHA, T. L.; SILVA, L.; FRANCO, O. L.; VASCONCELOS, I.; OLIVEIRA, J. T.; CASTRO, C. F.; GROSSI DE SÁ, M. F.; LEONARDECZ, E. Phytochemical and toxicological evaluation of proteins isolated from cagaita (E. Dysenterica) with laxative properties. In: ANNUAL MEETING OF SBBQ, 37.; CONGRESS OF THE PABMB, 11., 2008, Águas de Lindóia, SP. Abstracts... Águas de Lindóia: SBBq, 2008. 1 CD-ROM.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 14. | | OLIVEIRA, R. S. de; OLIVEIRA NETO, O. B. de; WANCHAO, N.; COSTA, P. H. A. da; EVANGELISTA, I. B. R.; LEONARDECZ, E.; ROMANO, E.; COUTINHO, M. V.; VIANA, A. A. B.; SILVA, M. C. M. da S.; ROCHA, T. L.; GROSSI DE SÁ, M. F. Transformação de algodoeiro via tubo polínico: otimização e perspectivas de aplicação. Brasília, DF: Embrapa Recursos Genéticos e Biotecnologia, 2007. 30 p. (Embrapa Recursos Genéticos e Biotecnologia. Boletim de pesquisa e desenvolvimento, 184).| Tipo: Boletim de Pesquisa e Desenvolvimento |
| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| Registros recuperados : 14 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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